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Commonly used FRET fluorophores promote collapse of an otherwise disordered protein

The dimensions that unfolded proteins, including intrinsically disordered proteins (IDPs), adopt in the absence of denaturant remain controversial. We developed an analysis procedure for small-angle X-ray scattering (SAXS) profiles and used it to demonstrate that even relatively hydrophobic IDPs rem...

詳細記述

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書誌詳細
出版年:Proc Natl Acad Sci U S A
主要な著者: Riback, Joshua A., Bowman, Micayla A., Zmyslowski, Adam M., Plaxco, Kevin W., Clark, Patricia L., Sosnick, Tobin R.
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2019
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6500129/
https://ncbi.nlm.nih.gov/pubmed/30992378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1813038116
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