SWI/SNF component ARID1A restrains pancreatic neoplasia formation

OBJECTIVE: ARID1A is commonly mutated in pancreatic ductal adenocarcinoma (PDAC), but the functional effects of ARID1A mutations in the pancreas are unclear. Understanding the molecular mechanisms that drive PDAC formation may lead to novel therapies. DESIGN: Concurrent conditional Arid1a deletion a...

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Dettagli Bibliografici
Pubblicato in:Gut
Autori principali: Wang, Sam C, Nassour, Ibrahim, Xiao, Shu, Zhang, Shuyuan, Luo, Xin, Lee, Jeon, Li, Lin, Sun, Xuxu, Nguyen, Liem H, Chuang, Jen-Chieh, Peng, Lan, Daigle, Scott, Shen, Jeanne, Zhu, Hao
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMJ Publishing Group 2019
Soggetti:
Pancreas
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6499717/
https://ncbi.nlm.nih.gov/pubmed/30315093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2017-315490
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