Suppression of the SWI/SNF component Arid1a promotes mammalian regeneration

Mammals have partially lost the extensive regenerative capabilities of some vertebrates, possibly as a result of chromatin-remodeling mechanisms that enforce terminal differentiation. Here, we show that deleting the SWI/SNF component Arid1a substantially improves mammalian regeneration. Arid1a expre...

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Publicat a:Cell Stem Cell
Autors principals: Sun, Xuxu, Chuang, Jen-Chieh, Kanchwala, Mohammed, Wu, Linwei, Celen, Cemre, Li, Lin, Liang, Hanquan, Zhang, Shuyuan, Maples, Thomas, Nguyen, Liem H., Wang, Sam C., Signer, Robert A. J., Sorouri, Mahsa, Nassour, Ibrahim, Liu, Xin, Xu, Jian, Wu, Meng, Zhao, Yong, Kuo, Yi-Chun, Wang, Zhong, Xing, Chao, Zhu, Hao
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4826298/
https://ncbi.nlm.nih.gov/pubmed/27044474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2016.03.001
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