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High Hes1 expression and resultant Ascl1 suppression regulate quiescent vs. active neural stem cells in the adult mouse brain

Somatic stem/progenitor cells are active in embryonic tissues but quiescent in many adult tissues. The detailed mechanisms that regulate active versus quiescent stem cell states are largely unknown. In active neural stem cells, Hes1 expression oscillates and drives cyclic expression of the proneural...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Genes Dev
Main Authors: Sueda, Risa, Imayoshi, Itaru, Harima, Yukiko, Kageyama, Ryoichiro
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 2019
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6499325/
https://ncbi.nlm.nih.gov/pubmed/30862661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.323196.118
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