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The cyclic gene Hes1 contributes to diverse differentiation responses of embryonic stem cells

Stem cells do not all respond the same way, but the mechanisms underlying this heterogeneity are not well understood. Here, we found that expression of Hes1 and its downstream genes oscillate in mouse embryonic stem (ES) cells. Those expressing low and high levels of Hes1 tended to differentiate int...

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Detalles Bibliográficos
Main Authors: Kobayashi, Taeko, Mizuno, Hiroaki, Imayoshi, Itaru, Furusawa, Chikara, Shirahige, Katsuhiko, Kageyama, Ryoichiro
Formato: Artigo
Idioma:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2009
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2725939/
https://ncbi.nlm.nih.gov/pubmed/19684110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1823109
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