The cyclic gene Hes1 contributes to diverse differentiation responses of embryonic stem cells

Stem cells do not all respond the same way, but the mechanisms underlying this heterogeneity are not well understood. Here, we found that expression of Hes1 and its downstream genes oscillate in mouse embryonic stem (ES) cells. Those expressing low and high levels of Hes1 tended to differentiate int...

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Bibliografiske detaljer
Main Authors: Kobayashi, Taeko, Mizuno, Hiroaki, Imayoshi, Itaru, Furusawa, Chikara, Shirahige, Katsuhiko, Kageyama, Ryoichiro
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2009
Fag:
Research Communication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2725939/
https://ncbi.nlm.nih.gov/pubmed/19684110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1823109
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