Enhanced lysosomal degradation maintains the quiescent state of neural stem cells

Quiescence is important for sustaining neural stem cells (NSCs) in the adult brain over the lifespan. Lysosomes are digestive organelles that degrade membrane receptors after they undergo endolysosomal membrane trafficking. Enlarged lysosomes are present in quiescent NSCs (qNSCs) in the subventricul...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Kobayashi, Taeko, Piao, Wenhui, Takamura, Toshiya, Kori, Hiroshi, Miyachi, Hitoshi, Kitano, Satsuki, Iwamoto, Yumiko, Yamada, Mayumi, Imayoshi, Itaru, Shioda, Seiji, Ballabio, Andrea, Kageyama, Ryoichiro
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6884460/
https://ncbi.nlm.nih.gov/pubmed/31784517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13203-4
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