PD-1 Dynamically Regulates Inflammation and Development of Brain-Resident Memory CD8 T Cells During Persistent Viral Encephalitis

Programmed cell death-1 (PD-1) receptor signaling dampens the functionality of T cells faced with repetitive antigenic stimulation from chronic infections or tumors. Using intracerebral (i.c.) inoculation with mouse polyomavirus (MuPyV), we have shown that CD8 T cells establish a PD-1(hi), tissue-re...

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Pubblicato in:Front Immunol
Autori principali: Shwetank, Frost, Elizabeth L., Mockus, Taryn E., Ren, Heather M., Toprak, Mesut, Lauver, Matthew D., Netherby-Winslow, Colleen S., Jin, Ge, Cosby, Jennifer M., Evavold, Brian D., Lukacher, Aron E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2019
Soggetti:
Immunology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6499176/
https://ncbi.nlm.nih.gov/pubmed/31105690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.00783
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