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IL-21 from high-affinity CD4 T cells drives differentiation of brain-resident CD8 T cells during persistent viral infection
Development of tissue resident-memory CD8 T cells (T(RM)) depends on CD4 T cells. In polyomavirus CNS infection, brain CXCR5(hi) PD-1(hi) CD4 T cells produce IL-21 and CD8 T cells lacking IL-21 receptors (IL21R(−/−)) fail to become bT(RM). IL-21(+) CD4 T cells exhibit elevated TCR affinity and highe...
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| Publicado no: | Sci Immunol |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7721466/ https://ncbi.nlm.nih.gov/pubmed/32948671 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.abb5590 |
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