Sequential Immunization With Live-Attenuated Chimeric Hemagglutinin-Based Vaccines Confers Heterosubtypic Immunity Against Influenza A Viruses in a Preclinical Ferret Model

Due to continuous antigenic drift and occasional antigenic shift, influenza viruses escape from human adaptive immunity resulting in significant morbidity and mortality in humans. Therefore, to avoid the need for annual reformulation and readministration of seasonal influenza virus vaccines, we are...

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Dettagli Bibliografici
Pubblicato in:Front Immunol
Autori principali: Liu, Wen-Chun, Nachbagauer, Raffael, Stadlbauer, Daniel, Solórzano, Alicia, Berlanda-Scorza, Francesco, García-Sastre, Adolfo, Palese, Peter, Krammer, Florian, Albrecht, Randy A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2019
Soggetti:
Immunology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6499175/
https://ncbi.nlm.nih.gov/pubmed/31105689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.00756
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