Sequential Immunization With Live-Attenuated Chimeric Hemagglutinin-Based Vaccines Confers Heterosubtypic Immunity Against Influenza A Viruses in a Preclinical Ferret Model

Due to continuous antigenic drift and occasional antigenic shift, influenza viruses escape from human adaptive immunity resulting in significant morbidity and mortality in humans. Therefore, to avoid the need for annual reformulation and readministration of seasonal influenza virus vaccines, we are...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Liu, Wen-Chun, Nachbagauer, Raffael, Stadlbauer, Daniel, Solórzano, Alicia, Berlanda-Scorza, Francesco, García-Sastre, Adolfo, Palese, Peter, Krammer, Florian, Albrecht, Randy A.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6499175/
https://ncbi.nlm.nih.gov/pubmed/31105689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.00756
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