Chimeric Hemagglutinin-Based Live-Attenuated Vaccines Confer Durable Protective Immunity against Influenza A Viruses in a Preclinical Ferret Model

Epidemic or pandemic influenza can annually cause significant morbidity and mortality in humans. We developed novel chimeric hemagglutinin (cHA)-based universal influenza virus vaccines, which contain a conserved HA stalk domain from a 2009 pandemic H1N1 (pH1N1) strain combined with globular head do...

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Bibliografiske detaljer
Udgivet i:Vaccines (Basel)
Main Authors: Liu, Wen-Chun, Nachbagauer, Raffael, Stadlbauer, Daniel, Strohmeier, Shirin, Solórzano, Alicia, Berlanda-Scorza, Francesco, Innis, Bruce L., García-Sastre, Adolfo, Palese, Peter, Krammer, Florian, Albrecht, Randy A.
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7826668/
https://ncbi.nlm.nih.gov/pubmed/33440898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/vaccines9010040
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