p95HER2–T cell bispecific antibody for breast cancer treatment

T cell bispecific antibodies (TCBs) are engineered molecules that include, within a single entity, binding sites to the T cell receptor and to tumor-associated or tumor-specific antigens. The receptor tyrosine kinase HER2 is a tumor-associated antigen in ~25% of breast cancers. TCBs targeting HER2 m...

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Publicat a:Sci Transl Med
Autors principals: Ruiz, Irene Rius, Vicario, Rocio, Morancho, Beatriz, Morales, Cristina Bernadó, Arenas, Enrique J., Herter, Sylvia, Freimoser-Grundschober, Anne, Somandin, Jitka, Sam, Johannes, Ast, Oliver, Barriocanal, Águeda Martinez, Luque, Antonio, Escorihuela, Marta, Varela, Ismael, Cuartas, Isabel, Nuciforo, Paolo, Fasani, Roberta, Peg, Vicente, Rubio, Isabel, Cortés, Javier, Serra, Violeta, Escriva-de-Romani, Santiago, Sperinde, Jeff, Chenna, Ahmed, Huang, Weidong, Winslow, John, Albanell, Joan, Seoane, Joan, Scaltriti, Maurizio, Baselga, Jose, Tabernero, Josep, Umana, Pablo, Bacac, Marina, Saura, Cristina, Klein, Christian, Arribas, Joaquín
Format: Artigo
Idioma:Inglês
Publicat: 2018
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6498439/
https://ncbi.nlm.nih.gov/pubmed/30282693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aat1445
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