Microsatellite instability due to hMLH1 deficiency is associated with increased cytotoxicity to irinotecan in human colorectal cancer cell lines

Around 15% of colorectal cancers (CRCs) show microsatellite instability (MSI) due to dysfunction of the mismatch repair system (MMR). As a consequence of this, MSI tumours tend to accumulate errors in mononucleotide repeats as those in genes implicated in repairing double-strand breaks (DSBs). Previ...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Vilar, E, Scaltriti, M, Balmaña, J, Saura, C, Guzman, M, Arribas, J, Baselga, J, Tabernero, J
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2008
Sujets:
Translational Therapeutics
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2584960/
https://ncbi.nlm.nih.gov/pubmed/18941461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6604691
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires