Microsatellite instability due to hMLH1 deficiency is associated with increased cytotoxicity to irinotecan in human colorectal cancer cell lines

Around 15% of colorectal cancers (CRCs) show microsatellite instability (MSI) due to dysfunction of the mismatch repair system (MMR). As a consequence of this, MSI tumours tend to accumulate errors in mononucleotide repeats as those in genes implicated in repairing double-strand breaks (DSBs). Previ...

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Autors principals: Vilar, E, Scaltriti, M, Balmaña, J, Saura, C, Guzman, M, Arribas, J, Baselga, J, Tabernero, J
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2008
Matèries:
Translational Therapeutics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2584960/
https://ncbi.nlm.nih.gov/pubmed/18941461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6604691
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