Patterns of HER2 Gene Amplification and Response to Anti-HER2 Therapies

A chromosomal region that includes the gene encoding HER2, a receptor tyrosine kinase (RTK), is amplified in 20% of breast cancers. Although these tumors tend to respond to drugs directed against HER2, they frequently become resistant and resume their malignant progression. Gene amplification in dou...

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Bibliografiska uppgifter
I publikationen:PLoS One
Huvudupphovsmän: Vicario, Rocio, Peg, Vicente, Morancho, Beatriz, Zacarias-Fluck, Mariano, Zhang, Junjie, Martínez-Barriocanal, Águeda, Navarro Jiménez, Alexandra, Aura, Claudia, Burgues, Octavio, Lluch, Ana, Cortés, Javier, Nuciforo, Paolo, Rubio, Isabel T., Marangoni, Elisabetta, Deeds, James, Boehm, Markus, Schlegel, Robert, Tabernero, Josep, Mosher, Rebecca, Arribas, Joaquín
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2015
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4467984/
https://ncbi.nlm.nih.gov/pubmed/26075403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0129876
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