Patterns of HER2 Gene Amplification and Response to Anti-HER2 Therapies

A chromosomal region that includes the gene encoding HER2, a receptor tyrosine kinase (RTK), is amplified in 20% of breast cancers. Although these tumors tend to respond to drugs directed against HER2, they frequently become resistant and resume their malignant progression. Gene amplification in dou...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Vicario, Rocio, Peg, Vicente, Morancho, Beatriz, Zacarias-Fluck, Mariano, Zhang, Junjie, Martínez-Barriocanal, Águeda, Navarro Jiménez, Alexandra, Aura, Claudia, Burgues, Octavio, Lluch, Ana, Cortés, Javier, Nuciforo, Paolo, Rubio, Isabel T., Marangoni, Elisabetta, Deeds, James, Boehm, Markus, Schlegel, Robert, Tabernero, Josep, Mosher, Rebecca, Arribas, Joaquín
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4467984/
https://ncbi.nlm.nih.gov/pubmed/26075403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0129876
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