Development of an ORF45-Derived Peptide To Inhibit the Sustained RSK Activation and Lytic Replication of Kaposi's Sarcoma-Associated Herpesvirus

The lytic replication of Kaposi’s sarcoma-associated herpesvirus (KSHV) requires sustained extracellular signal-regulated kinase (ERK)-p90 ribosomal S6 kinase (RSK) activation, which is induced by an immediate early (IE) gene-encoded tegument protein called ORF45, to promote the late transcription a...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Virol
Auteurs principaux: Li, Xiaojuan, Huang, Lu, Xiao, Yunjun, Yao, Xiangyang, Long, Xubing, Zhu, Fanxiu, Kuang, Ersheng
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2019
Sujets:
Vaccines and Antiviral Agents
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6498066/
https://ncbi.nlm.nih.gov/pubmed/30842327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02154-18
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