Humanized Mouse Model of HIV-1 Latency with Enrichment of Latent Virus in PD-1(+) and TIGIT(+) CD4 T Cells

Combination anti-retroviral drug therapy (ART) potently suppresses HIV-1 replication but does not result in virus eradication or a cure. A major contributing factor is the long-term persistence of a reservoir of latently infected cells. To study this reservoir, we established a humanized mouse model...

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Detaylı Bibliyografya
Yayımlandı:J Virol
Asıl Yazarlar: Llewellyn, George N., Seclén, Eduardo, Wietgrefe, Stephen, Liu, Siyu, Chateau, Morgan, Pei, Hua, Perkey, Katherine, Marsden, Matthew D., Hinkley, Sarah J., Paschon, David E., Holmes, Michael C., Zack, Jerome A., Louie, Stan G., Haase, Ashley T., Cannon, Paula M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2019
Konular:
Pathogenesis and Immunity
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6498059/
https://ncbi.nlm.nih.gov/pubmed/30842333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02086-18
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