Humanized Mouse Model of HIV-1 Latency with Enrichment of Latent Virus in PD-1(+) and TIGIT(+) CD4 T Cells

Combination anti-retroviral drug therapy (ART) potently suppresses HIV-1 replication but does not result in virus eradication or a cure. A major contributing factor is the long-term persistence of a reservoir of latently infected cells. To study this reservoir, we established a humanized mouse model...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Llewellyn, George N., Seclén, Eduardo, Wietgrefe, Stephen, Liu, Siyu, Chateau, Morgan, Pei, Hua, Perkey, Katherine, Marsden, Matthew D., Hinkley, Sarah J., Paschon, David E., Holmes, Michael C., Zack, Jerome A., Louie, Stan G., Haase, Ashley T., Cannon, Paula M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2019
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6498059/
https://ncbi.nlm.nih.gov/pubmed/30842333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02086-18
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