A novel triazole, NMK-T-057, induces autophagic cell death in breast cancer cells by inhibiting γ-secretase–mediated activation of Notch signaling

Notch signaling is reported to be deregulated in several malignancies, including breast, and the enzyme γ-secretase plays an important role in the activation and nuclear translocation of Notch intracellular domain (NICD). Hence, pharmacological inhibition of γ-secretase might lead to the subsequent...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Biol Chem
Egile Nagusiak: Das, Amlan, Narayanam, Maruthi Kumar, Paul, Santanu, Mukhnerjee, Pritha, Ghosh, Suvranil, Dastidar, Debabrata Ghosh, Chakrabarty, Subhendu, Ganguli, Arnab, Basu, Biswarup, Pal, Mahadeb, Chatterji, Urmi, Banerjee, Sushanta K., Karmakar, Parimal, Kumar, Dalip, Chakrabarti, Gopal
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2019
Gaiak:
Cell Biology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6497959/
https://ncbi.nlm.nih.gov/pubmed/30824542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.007671
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak