A novel triazole, NMK-T-057, induces autophagic cell death in breast cancer cells by inhibiting γ-secretase–mediated activation of Notch signaling

Notch signaling is reported to be deregulated in several malignancies, including breast, and the enzyme γ-secretase plays an important role in the activation and nuclear translocation of Notch intracellular domain (NICD). Hence, pharmacological inhibition of γ-secretase might lead to the subsequent...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Principais autores: Das, Amlan, Narayanam, Maruthi Kumar, Paul, Santanu, Mukhnerjee, Pritha, Ghosh, Suvranil, Dastidar, Debabrata Ghosh, Chakrabarty, Subhendu, Ganguli, Arnab, Basu, Biswarup, Pal, Mahadeb, Chatterji, Urmi, Banerjee, Sushanta K., Karmakar, Parimal, Kumar, Dalip, Chakrabarti, Gopal
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6497959/
https://ncbi.nlm.nih.gov/pubmed/30824542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.007671
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