A novel triazole, NMK-T-057, induces autophagic cell death in breast cancer cells by inhibiting γ-secretase–mediated activation of Notch signaling

Notch signaling is reported to be deregulated in several malignancies, including breast, and the enzyme γ-secretase plays an important role in the activation and nuclear translocation of Notch intracellular domain (NICD). Hence, pharmacological inhibition of γ-secretase might lead to the subsequent...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Das, Amlan, Narayanam, Maruthi Kumar, Paul, Santanu, Mukhnerjee, Pritha, Ghosh, Suvranil, Dastidar, Debabrata Ghosh, Chakrabarty, Subhendu, Ganguli, Arnab, Basu, Biswarup, Pal, Mahadeb, Chatterji, Urmi, Banerjee, Sushanta K., Karmakar, Parimal, Kumar, Dalip, Chakrabarti, Gopal
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2019
Fag:
Cell Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6497959/
https://ncbi.nlm.nih.gov/pubmed/30824542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.007671
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker