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A stromal lysolipid-autotaxin signaling axis promotes pancreatic tumor progression

Pancreatic ductal adenocarcinoma (PDAC) develops a pronounced stromal response reflecting an aberrant wound-healing process. This stromal reaction features trans-differentiation of tissue-resident pancreatic stellate cells (PSCs) into activated cancer-associated fibroblasts (CAFs), a process induced...

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Bibliografische gegevens
Gepubliceerd in:Cancer Discov
Hoofdauteurs: Auciello, Francesca R., Bulusu, Vinay, Oon, Chet, Tait-Mulder, Jacqueline, Berry, Mark, Bhattacharyya, Sohinee, Tumanov, Sergey, Allen-Petersen, Brittany L., Link, Jason, Kendsersky, Nicholas D., Vringer, Esmee, Schug, Michelle, Novo, David, Hwang, Rosa F., Evans, Ronald M., Nixon, Colin, Dorrell, Craig, Morton, Jennifer P., Norman, Jim C., Sears, Rosalie C., Kamphorst, Jurre J., Sherman, Mara H.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6497553/
https://ncbi.nlm.nih.gov/pubmed/30837243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-18-1212
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