A stromal lysolipid-autotaxin signaling axis promotes pancreatic tumor progression

Pancreatic ductal adenocarcinoma (PDAC) develops a pronounced stromal response reflecting an aberrant wound-healing process. This stromal reaction features trans-differentiation of tissue-resident pancreatic stellate cells (PSCs) into activated cancer-associated fibroblasts (CAFs), a process induced...

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Publicado en:Cancer Discov
Main Authors: Auciello, Francesca R., Bulusu, Vinay, Oon, Chet, Tait-Mulder, Jacqueline, Berry, Mark, Bhattacharyya, Sohinee, Tumanov, Sergey, Allen-Petersen, Brittany L., Link, Jason, Kendsersky, Nicholas D., Vringer, Esmee, Schug, Michelle, Novo, David, Hwang, Rosa F., Evans, Ronald M., Nixon, Colin, Dorrell, Craig, Morton, Jennifer P., Norman, Jim C., Sears, Rosalie C., Kamphorst, Jurre J., Sherman, Mara H.
Formato: Artigo
Idioma:Inglês
Publicado: 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6497553/
https://ncbi.nlm.nih.gov/pubmed/30837243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-18-1212
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