A stromal lysolipid-autotaxin signaling axis promotes pancreatic tumor progression

Pancreatic ductal adenocarcinoma (PDAC) develops a pronounced stromal response reflecting an aberrant wound-healing process. This stromal reaction features trans-differentiation of tissue-resident pancreatic stellate cells (PSCs) into activated cancer-associated fibroblasts (CAFs), a process induced...

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Publicat a:Cancer Discov
Autors principals: Auciello, Francesca R., Bulusu, Vinay, Oon, Chet, Tait-Mulder, Jacqueline, Berry, Mark, Bhattacharyya, Sohinee, Tumanov, Sergey, Allen-Petersen, Brittany L., Link, Jason, Kendsersky, Nicholas D., Vringer, Esmee, Schug, Michelle, Novo, David, Hwang, Rosa F., Evans, Ronald M., Nixon, Colin, Dorrell, Craig, Morton, Jennifer P., Norman, Jim C., Sears, Rosalie C., Kamphorst, Jurre J., Sherman, Mara H.
Format: Artigo
Idioma:Inglês
Publicat: 2019
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6497553/
https://ncbi.nlm.nih.gov/pubmed/30837243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-18-1212
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