A stromal lysolipid-autotaxin signaling axis promotes pancreatic tumor progression

Pancreatic ductal adenocarcinoma (PDAC) develops a pronounced stromal response reflecting an aberrant wound-healing process. This stromal reaction features trans-differentiation of tissue-resident pancreatic stellate cells (PSCs) into activated cancer-associated fibroblasts (CAFs), a process induced...

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Publicado no:Cancer Discov
Main Authors: Auciello, Francesca R., Bulusu, Vinay, Oon, Chet, Tait-Mulder, Jacqueline, Berry, Mark, Bhattacharyya, Sohinee, Tumanov, Sergey, Allen-Petersen, Brittany L., Link, Jason, Kendsersky, Nicholas D., Vringer, Esmee, Schug, Michelle, Novo, David, Hwang, Rosa F., Evans, Ronald M., Nixon, Colin, Dorrell, Craig, Morton, Jennifer P., Norman, Jim C., Sears, Rosalie C., Kamphorst, Jurre J., Sherman, Mara H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6497553/
https://ncbi.nlm.nih.gov/pubmed/30837243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-18-1212
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