Acidic fibroblast growth factor underlies microenvironmental regulation of MYC in pancreatic cancer

Despite a critical role for MYC as an effector of oncogenic RAS, strategies to target MYC activity in RAS-driven cancers are lacking. In genetically engineered mouse models of lung and pancreatic cancer, oncogenic KRAS is insufficient to drive tumorigenesis, while addition of modest MYC overexpressi...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:J Exp Med
Auteurs principaux: Bhattacharyya, Sohinee, Oon, Chet, Kothari, Aayush, Horton, Wesley, Link, Jason, Sears, Rosalie C., Sherman, Mara H.
Format: Artigo
Langue:Inglês
Publié: Rockefeller University Press 2020
Sujets:
Brief Definitive Report
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7398167/
https://ncbi.nlm.nih.gov/pubmed/32434218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20191805
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires