Acidic fibroblast growth factor underlies microenvironmental regulation of MYC in pancreatic cancer

Despite a critical role for MYC as an effector of oncogenic RAS, strategies to target MYC activity in RAS-driven cancers are lacking. In genetically engineered mouse models of lung and pancreatic cancer, oncogenic KRAS is insufficient to drive tumorigenesis, while addition of modest MYC overexpressi...

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Bibliographic Details
Published in:J Exp Med
Main Authors: Bhattacharyya, Sohinee, Oon, Chet, Kothari, Aayush, Horton, Wesley, Link, Jason, Sears, Rosalie C., Sherman, Mara H.
Format: Artigo
Language:Inglês
Published: Rockefeller University Press 2020
Subjects:
Brief Definitive Report
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7398167/
https://ncbi.nlm.nih.gov/pubmed/32434218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20191805
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