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The global clonal complexity of the murine blood system declines throughout life and after serial transplantation

Although many recent studies describe the emergence and prevalence of “clonal hematopoiesis of indeterminate potential” in aged human populations, a systematic analysis of the numbers of clones supporting steady-state hematopoiesis throughout mammalian life is lacking. Previous efforts relied on tra...

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Bibliographische Detailangaben
Veröffentlicht in:Blood
Hauptverfasser: Ganuza, Miguel, Hall, Trent, Finkelstein, David, Wang, Yong-Dong, Chabot, Ashley, Kang, Guolian, Bi, Wenjian, Wu, Gang, McKinney-Freeman, Shannon
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2019
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6497513/
https://ncbi.nlm.nih.gov/pubmed/30782612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2018-09-873059
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