Murine hematopoietic stem cell activity is derived from pre-circulation embryos but not yolk sacs

The embryonic site of definitive hematopoietic stem cell (dHSC) origination has been debated for decades. Although an intra-embryonic origin is well supported, the yolk sac (YS) contribution to adult hematopoiesis remains controversial. The same developmental origin makes it difficult to identify sp...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Ganuza, Miguel, Chabot, Ashley, Tang, Xing, Bi, Wenjian, Natarajan, Sivaraman, Carter, Robert, Gawad, Charles, Kang, Guolian, Cheng, Yong, McKinney-Freeman, Shannon
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6302089/
https://ncbi.nlm.nih.gov/pubmed/30573729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07769-8
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