PIM kinase inhibitor, AZD1208, inhibits protein translation and induces autophagy in primary chronic lymphocytic leukemia cells

The PIM1, PIM2, and PIM3 serine/threonine kinases play a role in the proliferation and survival of cancer cells. Mice lacking these three kinases were viable. Further, in human hematological malignancies, these proteins are overexpressed making them suitable targets. Several small molecule inhibitor...

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Dades bibliogràfiques
Publicat a:Oncotarget
Autors principals: Cervantes-Gomez, Fabiola, Stellrecht, Christine M., Ayres, Mary L., Keating, Michael J., Wierda, William G., Gandhi, Varsha
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2019
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6497463/
https://ncbi.nlm.nih.gov/pubmed/31073371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.26876
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