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Genetically encoded reporters of protein kinase A activity reveal impact of substrate tethering

The complexity and specificity of many forms of signal transduction are widely suspected to require spatial microcompartmentation of protein kinase and phosphatase activities, yet current relevant imaging methods such as phosphorylation-specific antibodies or fluorescent peptide substrates require f...

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Detalhes bibliográficos
Main Authors: Zhang, Jin, Ma, Yuliang, Taylor, Susan S., Tsien, Roger Y.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2001
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC64972/
https://ncbi.nlm.nih.gov/pubmed/11752448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.211566798
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