Development, Validation of LC-MS/MS Method and Determination of Pharmacokinetic Parameters of the Stroke Neuroprotectant Neurounina-1 in Beagle Dog Plasma After Intravenous Administration

Neurounina-1 [chemical name: 7-nitro-5-phenyl-1-(pyrrolidin-1-ylmethyl)-1H-benzo[e][1,4]diazepin-2(3H)-one] is a new compound provided with relevant neuroprotective effect during stroke and in neonatal hypoxia by increasing the Na(+)/Ca(2+) exchanger (NCX) isoforms NCX1 and NCX2 activity. This study...

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Pubblicato in:Front Pharmacol
Autori principali: Severino, Beatrice, Corvino, Angela, Fiorino, Ferdinando, Frecentese, Francesco, Perissutti, Elisa, Caliendo, Giuseppe, Santagada, Vincenzo, Magli, Elisa, Molinaro, Pasquale, Pignataro, Giuseppe, Annunziato, Lucio, Antunes, Natalícia J., Rojas-Moscoso, Julio, de Freitas, Noedi L., Mendes, Gustavo D., De Nucci, Gilberto
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2019
Soggetti:
Pharmacology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6497007/
https://ncbi.nlm.nih.gov/pubmed/31073288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00432
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