Non-Natural Linker Configuration in 2,6-Dipeptidyl-Anthraquinones Enhances the Inhibition of TAR RNA Binding/Annealing Activities by HIV-1 NC and Tat Proteins

The HIV-1 nucleocapsid (NC) protein represents an excellent molecular target for the development of antiretrovirals by virtue of its well-characterized chaperone activities, which play pivotal roles in essential steps of the viral life cycle. Our ongoing search for candidates able to impair NC bindi...

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Publicado en:Bioconjug Chem
Autores principales: Sosic, Alice, Saccone, Irene, Carraro, Caterina, Kenderdine, Thomas, Gamba, Elia, Caliendo, Giuseppe, Corvino, Angela, Di Vaio, Paola, Fiorino, Ferdinando, Magli, Elisa, Perissutti, Elisa, Santagada, Vincenzo, Severino, Beatrice, Spada, Valentina, Fabris, Dan, Frecentese, Francesco, Gatto, Barbara
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7175782/
https://ncbi.nlm.nih.gov/pubmed/29791798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.bioconjchem.8b00104
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