Enzymatic and Structural Characterization of the Naegleria fowleri Glucokinase

Infection with the free-living amoeba Naegleria fowleri leads to life-threatening primary amoebic meningoencephalitis. Efficacious treatment options for these infections are limited, and the mortality rate is very high (∼98%). Parasite metabolism may provide suitable targets for therapeutic design....

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Veröffentlicht in:Antimicrob Agents Chemother
Hauptverfasser: Milanes, Jillian E., Suryadi, Jimmy, Abendroth, Jan, Van Voorhis, Wesley C., Barrett, Kayleigh F., Dranow, David M., Phan, Isabelle Q., Patrick, Stephen L., Rozema, Soren D., Khalifa, Muhammad M., Golden, Jennifer E., Morris, James C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2019
Schlagworte:
Experimental Therapeutics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6496100/
https://ncbi.nlm.nih.gov/pubmed/30783001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02410-18
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