BubR1 deficiency results in enhanced activation of MEK and ERKs upon microtubule stresses

Abstract.  Disruption of microtubules activates the spindle checkpoint, of which BubR1 is a major component. Our early studies show that BubR1 haplo‐insufficiency results in enhanced mitotic slippage in vitro and tumorigenesis in vivo. Objective: Given that both MAPKs/ERKs and MEK play an important...

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Enregistré dans:
Détails bibliographiques
Publié dans:Cell Prolif
Auteurs principaux: Yang, Y. L., Duan, Q., Guo, T. B., Wang, X. X., Ruan, Q., Xu, G. T., Zhang, J. W., Lu, Z. Y., Xu, M., Lu, L., Dai, W.
Format: Artigo
Langue:Inglês
Publié: Blackwell Publishing Ltd 2007
Sujets:
Original Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6495970/
https://ncbi.nlm.nih.gov/pubmed/17531083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2184.2007.00443.x
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