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BubR1 deficiency results in enhanced activation of MEK and ERKs upon microtubule stresses
Abstract. Disruption of microtubules activates the spindle checkpoint, of which BubR1 is a major component. Our early studies show that BubR1 haplo‐insufficiency results in enhanced mitotic slippage in vitro and tumorigenesis in vivo. Objective: Given that both MAPKs/ERKs and MEK play an important...
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| Publicado no: | Cell Prolif |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Publishing Ltd
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6495970/ https://ncbi.nlm.nih.gov/pubmed/17531083 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2184.2007.00443.x |
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