Transcriptional Control of BubR1 by p53 and Suppression of Centrosome Amplification by BubR1

Elimination of the regulatory mechanism underlying numeral homeostasis of centrosomes, as seen in cells lacking p53, results in abnormal amplification of centrosomes, which increases the frequency of chromosome segregation errors, and thus contributes to the chromosome instability frequently observe...

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Autori principali: Oikawa, Tatsuo, Okuda, Masaru, Ma, Zhiyong, Goorha, Rakesh, Tsujimoto, Hajime, Inokuma, Hisashi, Fukasawa, Kenji
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2005
Soggetti:
Chromosome Structure and Dynamics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1087701/
https://ncbi.nlm.nih.gov/pubmed/15870277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.10.4046-4061.2005
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