Transcriptional Control of BubR1 by p53 and Suppression of Centrosome Amplification by BubR1

Elimination of the regulatory mechanism underlying numeral homeostasis of centrosomes, as seen in cells lacking p53, results in abnormal amplification of centrosomes, which increases the frequency of chromosome segregation errors, and thus contributes to the chromosome instability frequently observe...

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Autors principals: Oikawa, Tatsuo, Okuda, Masaru, Ma, Zhiyong, Goorha, Rakesh, Tsujimoto, Hajime, Inokuma, Hisashi, Fukasawa, Kenji
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2005
Matèries:
Chromosome Structure and Dynamics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1087701/
https://ncbi.nlm.nih.gov/pubmed/15870277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.10.4046-4061.2005
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