Effects of PI3‐k/Akt short hairpin RNA on proliferation, fibronectin production and synthesis of thrombospondin‐1 and transforming growth factor‐β(1) in glomerular mesangial cells induced by sublytic C5b‐9 complexes

Objectives: To explore proliferation of glomerular mesangial cells (GMC) and secretion of extracelluar matrix (fibronectin induced by sublytic C5b‐9 complexes), and then ascertain the role of phosphatidylinositol 3‐kinase (PI3‐k)/Akt signal pathway in these processes, by using small hairpin RNAs. Ma...

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Detalhes bibliográficos
Publicado no:Cell Prolif
Main Authors: Gao, L., Zhang, Y., Qiu, W., Xu, W., Feng, X., Ren, J., Jiang, X., Wang, H., Zhao, D., Wang, Y.
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2009
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6495855/
https://ncbi.nlm.nih.gov/pubmed/19143766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2184.2008.00575.x
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