Sublytic C5b-9 induces glomerular mesangial cell proliferation via ERK1/2-dependent SOX9 phosphorylation and acetylation by enhancing Cyclin D1 in rat Thy-1 nephritis

Glomerular mesangial cell (GMC) proliferation is a histopathological alteration in human mesangioproliferative glomerulonephritis (MsPGN) or in animal models of MsPGN, e.g., the rat Thy‐1 nephritis (Thy-1N) model. Although sublytic C5b-9 assembly on the GMC membrane can trigger cell proliferation, t...

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Publicat a:Exp Mol Med
Autors principals: Xie, Mengxiao, Wu, Zhijiao, Ying, Shuai, Liu, Longfei, Zhao, Chenhui, Yao, Chunlei, Zhang, Zhiwei, Luo, Can, Wang, Wenbo, Zhao, Dan, Zhang, Jing, Qiu, Wen, Wang, Yingwei
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8102557/
https://ncbi.nlm.nih.gov/pubmed/33811247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s12276-021-00589-9
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