Sublytic C5b-9 Complexes Induce Apoptosis of Glomerular Mesangial Cells in Rats with Thy-1 Nephritis through Role of Interferon Regulatory Factor-1-dependent Caspase 8 Activation

The apoptosis of glomerular mesangial cells (GMC) in rat Thy-1 nephritis (Thy-1N), a model of human mesangioproliferative glomerulonephritis, is accompanied by sublytic C5b-9 deposition, but the mechanism of sublytic C5b-9-mediated GMC apoptosis has not been elucidated. In the present study, the gen...

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Detalhes bibliográficos
Main Authors: Liu, Lisha, Qiu, Wen, Wang, Hui, Li, Yan, Zhou, Jianbo, Xia, Mei, Shan, Kai, Pang, Rongrong, Zhou, Ying, Zhao, Dan, Wang, Yingwei
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3351322/
https://ncbi.nlm.nih.gov/pubmed/22427665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.319566
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