Sublytic C5b-9 triggers glomerular mesangial cell apoptosis via XAF1 gene activation mediated by p300-dependent IRF-1 acetylation

The apoptosis of glomerular mesangial cells (GMCs) in rat Thy-1 nephritis (Thy-1N), a model of human mesangioproliferative glomerulonephritis (MsPGN), is accompanied by sublytic C5b-9 deposition. However, the mechanism by which sublytic C5b-9 induces GMC apoptosis is unclear. In the present studies,...

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Detalhes bibliográficos
Main Authors: Qiu, W, Zhou, J, Zhu, G, Zhao, D, He, F, Zhang, J, Lu, Y, Yu, T, Liu, L, Wang, Y
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4001307/
https://ncbi.nlm.nih.gov/pubmed/24743731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.153
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