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A mathematical model of the regulation of the G(1) phase of Rb+/+ and Rb−/− mouse embryonic fibroblasts and an osteosarcoma cell line
A mathematical model integrating the roles of cyclin D, cdk4, cyclin E, cdk2, E2F and RB in control of the G(1) phase of the cell cycle is described. Experimental results described with murine embryo fibroblasts (MEFs), either Rb+/+ or Rb−/−, and with the RB‐deficient osteosarcoma cell line, Saos‐2,...
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| Publicado no: | Cell Prolif |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Science Ltd
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6495694/ https://ncbi.nlm.nih.gov/pubmed/9375029 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2184.1997.00078.x |
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