Transdifferentiation of Mouse Embryonic Fibroblasts into Dopaminergic Neurons Reactivates LINE-1 Repetitive Elements

In mammals, LINE-1 (L1) retrotransposons constitute between 15% and 20% of the genome. Although only a few copies have retained the ability to retrotranspose, evidence in brain and differentiating pluripotent cells indicates that L1 retrotransposition occurs and creates mosaics in normal somatic tis...

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發表在:Stem Cell Reports
Main Authors: Della Valle, Francesco, Thimma, Manjula P., Caiazzo, Massimiliano, Pulcrano, Salvatore, Celii, Mirko, Adroub, Sabir A., Liu, Peng, Alanis-Lobato, Gregorio, Broccoli, Vania, Orlando, Valerio
格式: Artigo
語言:Inglês
出版: Elsevier 2020
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6962658/
https://ncbi.nlm.nih.gov/pubmed/31902705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2019.12.002
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