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Probing H(2)O(2)-mediated Structural Dynamics of the Human 26S Proteasome Using Quantitative Cross-linking Mass Spectrometry (QXL-MS)

Cytotoxic protein aggregation-induced impairment of cell function and homeostasis are hallmarks of age-related neurodegenerative pathologies. As proteasomal degradation represents the major clearance pathway for oxidatively damaged proteins, a detailed understanding of the molecular events underlyin...

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Detalhes bibliográficos
Publicado no:Mol Cell Proteomics
Main Authors: Yu, Clinton, Wang, Xiaorong, Huszagh, Alexander Scott, Viner, Rosa, Novitsky, Eric, Rychnovsky, Scott D., Huang, Lan
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6495261/
https://ncbi.nlm.nih.gov/pubmed/30723094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.TIR119.001323
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