The proteasome-interacting Ecm29 protein disassembles the 26S proteasome in response to oxidative stress

Oxidative stress has been implicated in multiple human neurological and other disorders. Proteasomes are multi-subunit proteases critical for the removal of oxidatively damaged proteins. To understand stress-associated human pathologies, it is important to uncover the molecular events underlying the...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Wang, Xiaorong, Chemmama, Ilan E., Yu, Clinton, Huszagh, Alexander, Xu, Yue, Viner, Rosa, Block, Sarah A., Cimermancic, Peter, Rychnovsky, Scott D., Ye, Yihong, Sali, Andrej, Huang, Lan
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2017
Schlagworte:
Protein Synthesis and Degradation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5625060/
https://ncbi.nlm.nih.gov/pubmed/28821611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.803619
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