Trioxane-based MS-cleavable cross-linking mass spectrometry for profiling multimeric interactions of cellular networks

Abstract Cross-linking mass spectrometry (XL-MS) is a powerful technology for mapping protein-protein interactions (PPIs) at the systems level. While bivalent cross-links are effective for defining protein interactions and structures, multivalent cross-links offer enhanced spatial resolution to faci...

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Detalhes bibliográficos

Principais autores:	Clinton Yu, Eric Novitsky, Sree Ganesh Balasubramani, Xiaorong Wang, Xiyu Shen, Qin Yang, Scott Rychnovsky, Ignacia Echeverria, Lan Huang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2025-07-01
coleção:	Nature Communications
Acesso em linha:	https://doi.org/10.1038/s41467-025-60642-3
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