Lipoprotein(a) and Oxidized Phospholipids Promote Valve Calcification in Patients With Aortic Stenosis

BACKGROUND: Lipoprotein(a) [Lp(a)], a major carrier of oxidized phospholipids (OxPL), is associated with an increased incidence of aortic stenosis (AS). However, it remains unclear whether elevated Lp(a) and OxPL drive disease progression and are therefore targets for therapeutic intervention. OBJEC...

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Опубликовано в: :J Am Coll Cardiol
Главные авторы: Zheng, Kang H., Tsimikas, Sotirios, Pawade, Tania, Kroon, Jeffrey, Jenkins, William S.A., Doris, Mhairi K., White, Audrey C., Timmers, Nyanza K.L.M., Hjortnaes, Jesper, Rogers, Maximillian A., Aikawa, Elena, Arsenault, Benoit J., Witztum, Joseph L., Newby, David E., Koschinsky, Marlys L., Fayad, Zahi A., Stroes, Erik S.G., Boekholdt, S. Matthijs, Dweck, Marc R.
Формат: Artigo
Язык:Inglês
Опубликовано: Elsevier Biomedical 2019
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6494952/
https://ncbi.nlm.nih.gov/pubmed/31047003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacc.2019.01.070
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