Lipoprotein(a) and Oxidized Phospholipids Promote Valve Calcification in Patients With Aortic Stenosis

BACKGROUND: Lipoprotein(a) [Lp(a)], a major carrier of oxidized phospholipids (OxPL), is associated with an increased incidence of aortic stenosis (AS). However, it remains unclear whether elevated Lp(a) and OxPL drive disease progression and are therefore targets for therapeutic intervention. OBJEC...

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Gepubliceerd in:J Am Coll Cardiol
Hoofdauteurs: Zheng, Kang H., Tsimikas, Sotirios, Pawade, Tania, Kroon, Jeffrey, Jenkins, William S.A., Doris, Mhairi K., White, Audrey C., Timmers, Nyanza K.L.M., Hjortnaes, Jesper, Rogers, Maximillian A., Aikawa, Elena, Arsenault, Benoit J., Witztum, Joseph L., Newby, David E., Koschinsky, Marlys L., Fayad, Zahi A., Stroes, Erik S.G., Boekholdt, S. Matthijs, Dweck, Marc R.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Elsevier Biomedical 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6494952/
https://ncbi.nlm.nih.gov/pubmed/31047003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacc.2019.01.070
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