Lipoprotein(a) and Oxidized Phospholipids Promote Valve Calcification in Patients With Aortic Stenosis

BACKGROUND: Lipoprotein(a) [Lp(a)], a major carrier of oxidized phospholipids (OxPL), is associated with an increased incidence of aortic stenosis (AS). However, it remains unclear whether elevated Lp(a) and OxPL drive disease progression and are therefore targets for therapeutic intervention. OBJEC...

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Udgivet i:J Am Coll Cardiol
Main Authors: Zheng, Kang H., Tsimikas, Sotirios, Pawade, Tania, Kroon, Jeffrey, Jenkins, William S.A., Doris, Mhairi K., White, Audrey C., Timmers, Nyanza K.L.M., Hjortnaes, Jesper, Rogers, Maximillian A., Aikawa, Elena, Arsenault, Benoit J., Witztum, Joseph L., Newby, David E., Koschinsky, Marlys L., Fayad, Zahi A., Stroes, Erik S.G., Boekholdt, S. Matthijs, Dweck, Marc R.
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier Biomedical 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6494952/
https://ncbi.nlm.nih.gov/pubmed/31047003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacc.2019.01.070
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