Mechanism-based tuning of insect 3,4-dihydroxyphenylacetaldehyde synthase for synthetic bioproduction of benzylisoquinoline alkaloids

Previous studies have utilized monoamine oxidase (MAO) and L-3,4-dihydroxyphenylalanine decarboxylase (DDC) for microbe-based production of tetrahydropapaveroline (THP), a benzylisoquinoline alkaloid (BIA) precursor to opioid analgesics. In the current study, a phylogenetically distinct Bombyx mori...

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Udgivet i:Nat Commun
Main Authors: Vavricka, Christopher J., Yoshida, Takanobu, Kuriya, Yuki, Takahashi, Shunsuke, Ogawa, Teppei, Ono, Fumie, Agari, Kazuko, Kiyota, Hiromasa, Li, Jianyong, Ishii, Jun, Tsuge, Kenji, Minami, Hiromichi, Araki, Michihiro, Hasunuma, Tomohisa, Kondo, Akihiko
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6494836/
https://ncbi.nlm.nih.gov/pubmed/31043610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09610-2
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