Mechanism-based tuning of insect 3,4-dihydroxyphenylacetaldehyde synthase for synthetic bioproduction of benzylisoquinoline alkaloids

Previous studies have utilized monoamine oxidase (MAO) and L-3,4-dihydroxyphenylalanine decarboxylase (DDC) for microbe-based production of tetrahydropapaveroline (THP), a benzylisoquinoline alkaloid (BIA) precursor to opioid analgesics. In the current study, a phylogenetically distinct Bombyx mori...

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Библиографические подробности
Опубликовано в: :Nat Commun
Главные авторы: Vavricka, Christopher J., Yoshida, Takanobu, Kuriya, Yuki, Takahashi, Shunsuke, Ogawa, Teppei, Ono, Fumie, Agari, Kazuko, Kiyota, Hiromasa, Li, Jianyong, Ishii, Jun, Tsuge, Kenji, Minami, Hiromichi, Araki, Michihiro, Hasunuma, Tomohisa, Kondo, Akihiko
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2019
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6494836/
https://ncbi.nlm.nih.gov/pubmed/31043610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09610-2
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